Inflammation and regeneration in cross-organs

The inflammation that accompanies injury and disease is a defense reaction, constituting an important part of the natural innate immune response. In any organ, inflammation is necessary for the healing process to reduce the size of a damaged or necrotic area and replace it with new tissue. When the necrotic area is replaced by new functional tissue, it is called regeneration; when it is instead replaced with abnormal scar tissue with prolonged inflammation, it is called fibrosis. Most organs will heal using a mixture of both mechanisms, and the inflammatory response is closely associated with these processes. The inflammation itself can support tissue protection and regeneration; however, it can also lead to further damage and dysfunction, like a double-edged sword. It is often difficult to recognize whether inflammation is harmful or beneficial for organ regeneration, since inflammatory reactions can be clinically, pathologically, and physiologically variable, depending on the cause and stage. In addition, a variety of inflammatory mediators finely orchestrate inflammation through extremely complicated cellular interactions, which makes inflammation nearly impossible to understand completely. Inflammation can be either therapeutic or exacerbating in different situations or organs, even when executed in the exact same manner. However, the act of mixing different insights from mutually irrelevant fields (organs or disease) can occasionally lead to the development of new insights. Indeed, in this manner, I have identified a new mechanism in the healing process following traumatic central nervous system (CNS) injury by examining the